circRNA basic information
circBase ID: hsa_circ_0000274
Name: -
Synonym: Circ_0000274
Host Gene: hsa-miR-338-3p
 
 
 
Disease basic information
DO ID:
 4450
DO name: renal cell carcinoma
Disease details: renal cell carcinoma
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: HUVECs, RCC cells (786-O, A498), normal cells (HK2) .
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-338-3p
Biological function: Knockdown of circ_0000274 RNA suppressed cell viability, colony formation, metastasis and tube formation and promoted apoptosis in RCC cells in vitro.
Molecular mechanism: Circ_0000274 RNA sponged hsa-miR-338-3p RNA to positively regulate NUCB2 protein in RCC cells.
Survival: -
Supported No.:
 1
Description:

Circ_0000274 RNA functioned as an oncogene in RCC development by regulating miR-338-3p RNA/NUCB2 protein axis and activating the JAK1/STAT3 protein signaling pathway.
Other information
Title:

Circ_0000274 contributes to renal cell carcinoma progression by regulating miR-338-3p/NUCB2 axis and JAK1/STAT3 pathway.

Journal: Transpl Immunol
Published: 2022/5/16
PubMed ID: 35569717