circRNA basic information
circBase ID: hsa_circ_0001273
Name: -
Synonym: Circ_0001273
Host Gene: hsa-miR-622
 
 
 
Disease basic information
DO ID:
 5041
DO name: esophageal cancer
Disease details: esophageal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human esophageal epithelial cells (HEEC, control), EC cell lines (KYSE30, KYSE180, TE1, ECA109)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-622
Biological function: Knockdown of circ_0001273 repressed EC cell proliferation, migration, epithelial-mesenchymal transition (EMT) and glutamine metabolism. Circ_0001273 knockdown also blocked tumor development in animal models.
Molecular mechanism: hsa-miR-622 was targeted by circ_0001273, and its inhibition reversed the functional effects of circ_0001273 knockdown. SLC1A5 was a target gene of hsa-miR-622, and circ_0001273 targeted hsa-miR-622 to positively regulate SLC1A5 expression.
Survival: -
Supported No.:
 1
Description:

Circ_0001273 high expression contributed to EC progression via modulating the miR-622/SLC1A5 signaling axis.
Other information
Title:

Circ_0001273 downregulation inhibits the growth, migration and glutamine metabolism of esophageal cancer cells via targeting the miR-622/SLC1A5 signaling axis.

Journal: Thorac Cancer
Published: 2022/5/15
PubMed ID: 35567340