circRNA basic information
circBase ID: hsa_circ_0000775
Name: -
Synonym: Circ_0000775
Host Gene: -
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatic carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal liver cell line (THLE-2), HC cell lines (HuH-7, Hep 3B, Li-7)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Circ_0000775 exacerbated HC cell migration, invasion and EMT through CDC27.
Molecular mechanism: Circ_0000775 in cytoplasm recruited IGF2BP2 to enhance the mRNA stability of CDC27, thus positively modulating CDC27 expression.
Survival: -
Supported No.:
 1
Description:

TCF7L2 promoted the transcription of circ_0000775, and circ_0000775 recruited IGF2BP2 to maintain CDC27 mRNA stability, thereby facilitating HC cell migration, invasion and EMT.
Other information
Title:

Circ_0000775 promotes the migration, invasion and EMT of hepatic carcinoma cells by recruiting IGF2BP2 to stabilize CDC27.

Journal: Pathol Res Pract
Published: 2022/5/14
PubMed ID: 35561648