circRNA basic information
circBase ID:
-
Name:
hsa_circ_TLR4
Synonym:
Circ-TLR4
Host Gene:
-
Disease basic information
DO ID:
114
DO name:
heart disease
Disease details:
cardiac hypertrophy
Species:
human
Species details:
human
Sample type:
tissue, cell line
Sample type details:
human cardiomyocytes (HCM) from left ventricular
circRNA-disease information
Detected method:
Q
Detected method confidence
High
Expression pattern:
UP
Associated gene:
-
Associated microRNA:
-
Biological function:
Circ-TLR4 knockdown attenuated angiotensin II (Ang II)-induced hypertrophy responses in cardiomyocytes.
Molecular mechanism:
circ-TLR4 positively regulated TLR4 expression through recruiting FUS to stabilize TLR4 mRNA. Furthermore, TLR4 overexpression rescued the cardiac responses mediated by circ-TLR4 silencing.
Survival:
-
Supported No.:
1
Description:
Circ-TLR4 promotes cardiac hypertrophy through recruiting FUS to stabilize TLR4 mRNA.
Other information
Title:
Circ-TLR4 promotes cardiac hypertrophy through recruiting FUS to stabilize TLR4 mRNA.
Journal:
J Interv Card Electrophysiol
Published:
2022/5/14
PubMed ID:
35553305