circRNA basic information
circBase ID: hsa_circ_0000514
Name: -
Synonym: Circ_0000514
Host Gene: hsa-miR-330-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: NSCLC cell lines (A549, H292, H226, CRL5800), normal human lung epithelial cells (BEAS-2B)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-330-5p
Biological function: Circ_0000514 significantly facilitated the growth, cell cycle progression, metastatic potential, and repressed the apoptosis of NSCLC cells.
Molecular mechanism: Circ_0000514 was identified as a molecular sponge to decoy hsa-miR-330-5p, and HMGA2 was proven to be a target gene of hsa-miR-330-5p.
Survival: -
Supported No.:
 1
Description:

Circ_0000514 is an oncogenic circRNA in NSCLC progression, and it modulates miR-330-5p/HMGA2 axis.
Other information
Title:

Circ_0000514 promotes the malignant biological behaviors of non-small cell lung cancer cells by modulating miR-330-5p and HMGA2.

Journal: Pathol Res Pract
Published: 2022/5/14
PubMed ID: 35552087