circRNA basic information
circBase ID: -
Name: hsa_circ_PTPRA
Synonym: circRNA_PTPRA
Host Gene: hsa-miR-582-3p
 
 
 
Disease basic information
DO ID:
 3910
DO name: lung adenocarcinoma
Disease details: lung adenocarcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: A549, NCI-H23, BEAS2B, 293_ cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-582-3p
Biological function: The overexpression of circRNA_PTPRA decreased cell proliferation and increased apoptotic cell numbers, whereas miR-582-3p overexpression reversed these effects.
Molecular mechanism: circRNA_PTPRA directly interacts with hsa-miR-582-3p and downregulates hsa-miR-582-3p expression in lung cancer cells.
Survival: -
Supported No.:
 1
Description:

These findings demonstrate that the up-regulation of circRNA_PTPRA significantly reduces lung cancer cell proliferation and induces apoptosis by regulating miR-582-3p expression.
Other information
Title:

CircRNA protein tyrosine phosphatase receptor type a suppresses proliferation and induces apoptosis of lung adenocarcinoma cells via regulation of microRNA-582-3p.

Journal: Bioengineered
Published: 2022/5/14
PubMed ID: 35549985