circRNA basic information
circBase ID: hsa_circ_0086414
Name: -
Synonym: Circular_0086414
Host Gene: hsa-miR-1290
 
 
 
Disease basic information
DO ID:
 5041
DO name: esophageal cancer
Disease details: esophageal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal human esophageal epithelial cells (Het-1A), EC cell lines (TE-10, KYSE150, TE-1, KYSE450)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-1290
Biological function: Increasing circ_0086414 expression led to decreased EC cell proliferation, invasion and glycolysis and increased cell apoptosis, accompanied by a decrease of N-cadherin expression and an increase of E-cadherin expression. Also, the enforced expression of circ_0086414 delayed tumor tumorigenesis.
Molecular mechanism: circ_0086414 acted as a hsa-miR-1290 sponge and regulated EC cell processes by binding to the miRNA. hsa-miR-1290 also participated in EC malignant progression through_PARCL1.
Survival: -
Supported No.:
 1
Description:

Thus, circ_0086414 inhibited EC cell malignancy through the miR-1290/SPARCL1_athway, providing a reliable target for the therapy of EC.
Other information
Title:

Circular_0086414 induces SPARC like 1 (SPARCL1) production to inhibit esophageal cancer cell proliferation, invasion and glycolysis and induce cell apoptosis by sponging miR-1290.

Journal: Bioengineered
Published: 2022/5/14
PubMed ID: 35549806