circRNA basic information
circBase ID: -
Name: hsa_circ_WEE1
Synonym: circWEE1
Host Gene: hsa-miR-195-5p
 
 
 
Disease basic information
DO ID:
 1380
DO name: endometrial cancer
Disease details: endometrial cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human EC cell lines (HEC-1-A, HEC-1B, KLE, Ishikawa), normal human endometrial epithelial cells (hEM15A)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-195-5p
Biological function: Over-expression of circWEE1 or down-regulation of miR-195-5p promoted cell migration and proliferation in EC.
Molecular mechanism: circWEE1 served as a sponge that directly targeted hsa-miR-195-5p. Bioinformatics prediction forecast that hsa-miR-195-5p directly targeted VEGF at 3-UTR,
Survival: -
Supported No.:
 1
Description:

Our findings indicate that Circular RNA hsa circWEE1/EIF4A3 promoted cell migration and proliferation in EC via VEGF signaling by miR-195-5p, which could provide pivotal potential therapeutic targets for the treatment of EC.
Other information
Title:

Circ 003390/Eukaryotic translation initiation factor 4A3 promoted cell migration and proliferation in endometrial cancer via vascular endothelial growth factor signaling by miR-195-5p.

Journal: Bioengineered
Published: 2022/5/14
PubMed ID: 35546509