circRNA basic information
circBase ID: hsa_circ_0006089
Name: -
Synonym: circ_0006089
Host Gene: hsa-miR-143-3p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: humans GC cell lines (HGC-27, BGC-823, AGS, MKN45), normal gastric epithelial immortalized cells (GES-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-143-3p
Biological function: circ_0006089 overexpression in GC cells significantly accelerated GC cell proliferation, migration and invasion, whereas circ_0006089 knockdown resulted in the opposite effects.
Molecular mechanism: hsa-miR-143-3p was validated as a downstream target of circ_0006089, and circ_0006089 could positively regulate IGF1R expression via repressing hsa-miR-143-3p.
Survival: poor
Supported No.:
 4
Description:

Circ_0006089 is highly expressed in GC, and it promotes the malignancy of GC cells via modulating miR-143-3p/IGF1R axis, suggesting that circ_0006089 may serve as a promising therapeutic target for GC.
Other information
Title:

Circular RNA circ_0006089 regulates the IGF1R expression by targeting miR-143-3p to promote gastric cancer proliferation, migration and invasion.

Journal: Cell Cycle
Published: 2022/5/13
PubMed ID: 35545863