circRNA basic information
circBase ID: -
Name: hsa_circ_RACGAP1
Synonym: circRACGAP1
Host Gene: hsa-miR-22-3p
 
 
 
Disease basic information
DO ID:
 9074
DO name: systemic lupus erythematosus
Disease details: systemic lupus erythematosus
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-22-3p
Biological function: Overexpression of circRACGAP1 significantly alleviated cell apoptosis in Jurkat cells within UVB exposure.
Molecular mechanism: Mechanistic investigation revealed that circRACGAP1 could serve as a sponge of hsa-miR-22-3p to regulate PTEN/AKT signalling.
Survival: -
Supported No.:
 1
Description:

Collectively, circRACGAP1 regulated the AKT signalling pathway_ia_inding to miR-22-3p in the progression of SLE, suggesting therapeutic targets for SLE treatment.
Other information
Title:

A novel circRNA, circRACGAP1, hampers the progression of systemic lupus erythematosus via miR-22-3p-mediated AKT signalling.

Journal: Autoimmunity
Published: 2022/5/12
PubMed ID: 35543435