circRNA basic information
circBase ID: hsa_circ_0039459
Name: -
Synonym: circ-0039459
Host Gene: hsa-miR-432
 
 
 
Disease basic information
DO ID:
 3571
DO name: liver cancer
Disease details: liver cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal liver epithelial cell line (THLE-3), hepatocellular carcinoma cell line (Hep3B, Huh7)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-432
Biological function: circ-0039459 knockdown or miR-432 overexpression can inhibit cell proliferation, invasion, and migration and the expression of N-cadherin and vimentin proteins in carcinoma cells as well as promote apoptosis and increase the E-cadherin level.
Molecular mechanism: circ-0039459 targeted and regulated hsa-miR-432, which targeted and regulated SYVN1. The decreased hsa-miR-432 expression reversed the effects of circ-0039459 knockout in cancer cells.
Survival: -
Supported No.:
 1
Description:

Hence, circ-0039459 can affect the proliferation, apoptosis, migration, and invasion of hepatocellular carcinoma cells through the adsorption of miR-432, thereby regulating the expression of SYVN1.
Other information
Title:

Circular RNA circRNA-0039459 promotes the migration, invasion, and proliferation of liver cancer cells through the adsorption of miR-432.

Journal: Bioengineered
Published: 2022/5/12
PubMed ID: 35543347