circRNA basic information
circBase ID: -
Name: hsa_circ_EBF1
Synonym: circEBF1
Host Gene: hsa-miR-1247-5p
 
 
 
Disease basic information
DO ID:
 3151
DO name: skin squamous cell carcinoma
Disease details: cutaneous squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human keratinocyte cell line (HaCaT), CSCC cell lines (SCC13, HSC5)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1247-5p
Biological function: Interference of circEBF1 hindered the proliferation, migration, invasion, and glycolysis of CSCC cells and promoted apoptosis.
Molecular mechanism: circEBF1 sponged hsa-miR-1247-5p to regulate CSCC cell development. Also, hsa-miR-1247-5p suppressed CSCC cell progression by inhibiting CSF3.
Survival: -
Supported No.:
 1
Description:

Down-regulation of circEBF1 impeded CSCC progression by regulating the miR-1247-5p/CSF3 pathway, suggesting that circEBF1 might be a promising therapeutic target for CSCC.
Other information
Title:

Knockdown of circRNA circEBF1 inhibits cutaneous squamous cell carcinoma progression by regulating the miR-1247-5p/CSF3 axis.

Journal: Histol Histopathol
Published: 2022/5/12
PubMed ID: 35543246