circRNA basic information
circBase ID: -
Name: hsa_circ_KCNQ5
Synonym: CircKCNQ5
Host Gene: hsa-miR-335-5p
 
 
 
Disease basic information
DO ID:
 9538
DO name: multiple myeloma
Disease details: myeloma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human normal plasma cells (nPCs) MM cells (MM1S, RPMI-8226, H929, U266, OPM2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-335-5p
Biological function: Importantly, knockdown of circKCNQ5 suppressed proliferation, migration, invasion, and glycolysis while it increased apoptosis of MM cells in vitro.
Molecular mechanism: the downregulation of hsa-miR-335-5p was able to rescue the circKCNQ5 inhibition-induced effects on MM cells. hsa-miR-335-5p interacted with circKCNQ5, and was able to target BRD4 in MM cells. hsa-miR-335-5p upregulation inhibited malignant phenotypes of MM cells depending on BRD4.
Survival: -
Supported No.:
 2
Description:

CircKCNQ5 was found to stimulate MM progression through competitively sponging to miR-335-5p.
Other information
Title:

CircKCNQ5 controls proliferation, migration, invasion, apoptosis, and glycolysis of multiple myeloma cells by modulating miR-335-5p/BRD4 axis.

Journal: Histol Histopathol
Published: 2022/5/11
PubMed ID: 35535987