circRNA basic information
circBase ID: -
Name: hsa_circ_USP36
Synonym: CircUSP36
Host Gene: hsa-miR-139-3p
 
 
 
Disease basic information
DO ID:
 6713
DO name: cerebrovascular disease
Disease details: ischemic stroke
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human glioblastoma cells (A172) , human 230 neuroblastoma cells (SH-SY5Y), human embryonic kidney cells (293T)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-139-3p
Biological function: circUSP36 silencing inhibited cellular activity and proliferation and promoted apoptosis after oxygen-glucose deprivation/reperfusion (OGD/R) treatment, while circUSP36 overexpression reversed these cellular phenotypes in vitro. Adeno-associated virus (AAV)-mediated overexpression of circUSP36 attenuates brain injury and neurological deficit and promotes motor function recovery of transient middle cerebral artery occlusion (tMCAO) mice.
Molecular mechanism: circUSP36 acts as a sponge to adsorb hsa-miR-139-3p, and hsa-miR-139-3p could bind and inhibit SMAD3 expression.
Survival: poor
Supported No.:
 1
Description:

In summary, we reveal for the first time that circUSP36 attenuates ischemic stroke injury through the miR-139-3p/SMAD3/Bcl2 signal axis, which make circUSP36 a potential therapeutic target for IS.
Other information
Title:

CircUSP36 attenuates ischemic stroke injury through the miR-139-3p/SMAD3/Bcl2 signal axis.

Journal: Clin Sci (Lond)
Published: 2022/5/10
PubMed ID: 35532376