circRNA basic information
circBase ID: -
Name: hsa_circ_ERBIN
Synonym: circERBIN
Host Gene: hsa-miR-1263
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: LM3, 97H cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1263
Biological function: Elevated circERBIN promoted G1/S transition of HCC cells, thus facilitating the proliferation and tumorigenesis of HCC cells.
Molecular mechanism: Mechanistic investigations revealed that circERBIN regulated HCC proliferation by acting as a sponge of hsa-miR-1263, which subsequently targeted cyclin dependent kinase 6 and controlled G1/S transition.
Survival: poor
Supported No.:
 1
Description:

Taken together, these results determined that circERBIN functions as an important epigenetic regulator in HCC development, highlighting that circERBIN is a promising target for treatment of HCC.
Other information
Title:

Circular RNA ERBIN Promotes Proliferation of Hepatocellular Carcinoma via the miR-1263/CDK6 Axis.

Journal: Front Oncol
Published: 2022/5/10
PubMed ID: 35530358