circRNA basic information
circBase ID: -
Name: hsa_circ_VAMP3
Synonym: circVAMP3
Host Gene: -
 
 
 
Disease basic information
DO ID:
 4450
DO name: renal cell carcinoma
Disease details: renal cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: A human renal proximal tubular epithelial cell line (HK-2), human RCC cell lines (786-O, Caki-2, A498, ACHN, OS-RC-1, OS-RC-2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: circVAMP3 expression was elevated in RCC patients in correspondence with TNM stage.
Molecular mechanism: circVAMP3 was observed to interact directly with lactate dehydrogenase A (LDHA) and modulate its activity. The circVAMP3-LDHA interaction facilitated LDHA phosphorylation at tyrosine 10 (Y10) catalyzed by the upstream kinase fibroblast growth factor receptor type 1 (FGFR1).
Survival: -
Supported No.:
 1
Description:

Therefore, this study reveals a novel molecular mechanism by which circVAMP3 promotes glycolysis and proliferation through regulating the enzymatic activity of glycolytic enzyme, suggesting that circVAMP3 may represent an RCC biomarker and treatment target.
Other information
Title:

Circular RNA circVAMP3 promotes aerobic glycolysis and proliferation by regulating LDHA in renal cell carcinoma.

Journal: Cell Death Dis
Published: 2022/5/8
PubMed ID: 35525866