circRNA basic information
circBase ID: -
Name: hsa_circ_MDK
Synonym: circMDK
Host Gene: hsa-miR-346, hsa-miR-874-3p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal human liver cell line (LO2), human HCC cell line (HCCLM3, SK-Hep-1, SMMC-7721, PLC/PRF/5, HepG2, HepG2-luc, Huh7, Hep3B)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-346, hsa-miR-874-3p
Biological function: circMDK sponged miR-346 and miR-874-3p to upregulate ATG16L1 (Autophagy Related 16 Like 1), resulting to the activation of PI3K/AKT/mTOR signaling pathway to promote cell proliferation, migration and invasion.
Molecular mechanism: circMDK sponged hsa-miR-346 and hsa-miR-874-3p to upregulate ATG16L1
Survival: poor
Supported No.:
 1
Description:

CircMDK could serve as a potential tumor biomarker that promotes the progression of HCC via the miR-346/874-3p-ATG16L1 axis. The PAE-based delivery of siRNA improved the stability and efficiency of siRNA targeting circMDK. The PAE-siRNA nanoparticles effectively inhibited HCC proliferation and metastasis in vivo. Our current findings offer a promising nanotherapeutic strategy for the treatment of HCC.
Other information
Title:

M6A-mediated upregulation of circMDK promotes tumorigenesis and acts as a nanotherapeutic target in hepatocellular carcinoma.

Journal: Mol Cancer
Published: 2022/5/8
PubMed ID: 35524319