circRNA basic information
circBase ID: hsa_circ_0005231
Name: -
Synonym: Circ_0005231
Host Gene: hsa-miR-383-5p
 
 
 
Disease basic information
DO ID:
 3748
DO name: esophagus squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: ESCC cells (TE_1, Eca_109), human normal esophageal cells (HET_1A)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-383-5p
Biological function: Cell proliferation, migration and invasion were significantly restrained by knockdown of circ_0005231 in ESCC cells.
Molecular mechanism: Circ_0005231 acted as a sponge of hsa-miR-383-5p, and circ_0005231 regulated ESCC cellular behavior by sponging hsa-miR-383-5p. Moreover, hsa-miR-383-5p directly targeted KIAA0101, and circ_0005231 positively regulated KIAA0101 expression by sponging hsa-miR-383-5p.
Survival: -
Supported No.:
 1
Description:

Circ_0005231 acted as a sponge of miR-383-5p to promote ESCC progression by upregulating KIAA0101, which provided a potential therapeutic strategy for ESCC treatment.
Other information
Title:

Circ_0005231 promotes the progression of esophageal squamous cell carcinoma via sponging miR-383-5p and regulating KIAA0101.

Journal: Thorac Cancer
Published: 2022/5/7
PubMed ID: 35524161