circRNA basic information
circBase ID: hsa_circ_0087429
Name: -
Synonym: circ_0087429
Host Gene: hsa-miR-5003-3p
 
 
 
Disease basic information
DO ID:
 4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: A human cervical immortalized squamous cell line (Ect1/E6E7), human cervical cancer cell lines (HeLa, SiHa, CaSki)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-5003-3p
Biological function: circ_0087429 can significantly inhibit the proliferation, migration, invasion and angiogenesis of cervical cancer in vitro and tumour growth and metastasis in vivo.
Molecular mechanism: circ_0087429 can upregulate the expression of OGN by competitively binding with hsa-miR-5003-3p, thereby reversing EMT and inhibiting the progression of cervical cancer. EIF4A3 can inhibit circ_0087429 expression by binding to its flanking regions.
Survival: -
Supported No.:
 1
Description:

As a tumour suppressor, circ_0087429 regulated by EIF4A3 can reverse EMT and inhibit the progression of cervical cancer through the miR-5003-3p/OGN axis. It is expected to become a potential target for the treatment of cervical cancer.
Other information
Title:

EIF4A3-regulated circ_0087429 can reverse EMT and inhibit the progression of cervical cancer via miR-5003-3p-dependent upregulation of OGN expression.

Journal: J Exp Clin Cancer Res
Published: 2022/5/6
PubMed ID: 35513835