circRNA basic information
circBase ID: -
Name: mmu_circ_PUM1
Synonym: circPUM1
Host Gene: mmu-miR-340-5p
 
 
 
Disease basic information
DO ID:
 326
DO name: ischemia
Disease details: Cerebral ischemia-reperfusion
Species: mouse
Species details: mouse
Sample type: cell line, PDX
Sample type details: SH-SY5Y cells
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: DDX5
Associated microRNA: mmu-miR-340-5p
Biological function: Knockdown of circPUM1 aggravated the neuronal injury in transient middle cerebral artery occlusion mice and motivated glial cell activation, neuronal apoptosis and inflammation. Enhancing circPUM1 restrained oxygen glucose deprivation/reoxygenation-induced SH-SY5Y cell apoptosis, the release of lactate dehydrogenase and inflammatory factors, and activation of nuclear factor-kappaB pathway, while elevating microRNA-340-5p aggravated oxygen glucose deprivation/reoxygenation-induced cell damage.
Molecular mechanism: circPUM1 competitively adsorbed microRNA-340-5p to mediate DEAD-box helicase 5.
Survival: -
Supported No.:
 1
Description:

this study clarifies that circPUM1 mitigates cerebral ischemia-reperfusion-induced neuronal injury by targeting the microRNA-340-5p/DEAD-box helicase 5 axis.
Other information
Title:

Circular RNA PUM1 performs as a competing endogenous RNA of microRNA-340-5p to mediate DEAD-box helicase 5 to mitigate cerebral ischemia-reperfusion injury.

Journal: Bioengineered
Published: 2022/5/6
PubMed ID: 35510394