circRNA basic information
circBase ID: -
Name: hsa_circ_LRP6
Synonym: -
Host Gene: hsa-miR-455
 
 
 
Disease basic information
DO ID:
 162
DO name: cancer
Disease details: cancer
Species: human
Species details: human
Sample type: cell line
Sample type details: HaCaT
circRNA-disease information
Detected method:
S
Detected method confidence Low
Expression pattern:
UP
Associated gene: ZEB1
Associated microRNA: hsa-miR-455
Biological function: -
Molecular mechanism: act as a sponge for hsa-miR-455 and up-regulate the hsa-miR-455 target, ZEB1, which subsequently induces the EMT, thus promoting malignant transformation
Survival: -
Supported No.:
 1
Description:

Thus, for HaCaT cells chronically exposed to arsenite, circLRP6 via miR-455 regulation of ZEB1 is involved in the EMT during malignant transformation. The results establish a previously unknown mechanism for arsenite-induced carcinogenesis.
Other information
Title:

CircLRP6 Regulation of ZEB1 via miR-455 Is Involved in the Epithelial-Mesenchymal Transition During Arsenite-Induced Malignant Transformation of Human Keratinocytes.

Journal: Toxicol Sci
Published: 2017/12/8
PubMed ID: 29216394