circRNA basic information
circBase ID: hsa_circ_0000811
Name: -
Synonym: Circ_0000811
Host Gene: hsa-miR-15b
 
 
 
Disease basic information
DO ID:
 2316
DO name: brain ischemia
Disease details: cerebral ischemia
Species: human
Species details: human
Sample type: PDX
Sample type details: mouse hippocampus neuron HT22 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-15b
Biological function: Our data then demonstrated that circ_0000811 restoration alleviated CI-induced vertigo in mouse models
Molecular mechanism: circ_0000811 acted as a hsa-miR-15b sponge to inhibit hsa-miR-15b expression. Prkar2a was validated as the target gene of hsa-miR-15b.
Survival: poor
Supported No.:
 1
Description:

Taken together, our work suggests that circ_0000811 is involved in neuronal apoptosis of CI-induced vertigo and may be used as a biomarker for ameliorating CI-induced vertigo.
Other information
Title:

Circ_0000811 acts as a miR-15b sponge and inhibits Prkar2a-mediated JAK2/STAT1 pathway to attenuate cerebral ischemic vertigo.

Journal: Cell Death Discov
Published: 2022/5/5
PubMed ID: 35508616