circRNA basic information
circBase ID: -
Name: hsa_circ_DHTKD1
Synonym: circDHTKD1
Host Gene: hsa-miR-149-5p
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: Bladder cancer cell lines (5637, T24, UMUC3), normal urothelial epithelial cell line (SV-HUC-1)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-149-5p
Biological function: we identified that circDHTKD1 facilitated lymphangiogenesis by upregulating CXCL5
Molecular mechanism: circDHTKD1 directly interacted with hsa-miR-149-5p, and antagonized the repression of hsa-miR-149-5p on CXCL5.
Survival: -
Supported No.:
 2
Description:

Our study supports circDHTKD1 as a promising diagnostic and therapeutic target for LN metastasis in BCa.
Other information
Title:

circDHTKD1 promotes lymphatic metastasis of bladder cancer by upregulating CXCL5.

Journal: Cell Death Discov
Published: 2022/5/4
PubMed ID: 35504887