circRNA basic information
circBase ID: -
Name: hsa_circ_ATRNL1
Synonym: CircATRNL1
Host Gene: hsa-miR-103a-3p
 
 
 
Disease basic information
DO ID:
 288
DO name: endometriosis of uterus
Disease details: endometriosis
Species: human
Species details: human
Sample type: cell line
Sample type details: HEC-B, AN3-CA, KLE, HEC1-A, Ishikawa
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-103a-3p
Biological function: CircATRNL1 silencing contributed to the decline of proliferation, invasion, migration, and EMT in Ishikawa cells, while miR-103a-3p inhibitor reversed those changes.
Molecular mechanism: circATRNL1 bound to hsa-miR-103a-3p to upregulate a target gene of hsa-miR-103a-3p, ASIC1.
Survival: -
Supported No.:
 1
Description:

Our study supported that circATRNL1 might be a novel therapeutic candidate target for endometriosis treatment and provided unique insights into the molecular basis concerning the pathogenesis of endometriosis.
Other information
Title:

CircATRNL1 increases acid-sensing ion channel 1 to advance epithelial-mesenchymal transition in endometriosis by binding to microRNA-103a-3p.

Journal: Reprod Biol
Published: 2022/5/4
PubMed ID: 35504053