circRNA basic information
circBase ID: -
Name: hsa_circ_MRPS35
Synonym: circMRPS35
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: MG63, MNNG/HOS cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: The overexpression of circMRPS35 induced the apoptosis and autophagy of osteosarcoma cells, in which the depletion of KAT6B or FOXO3 reversed the effect.
Molecular mechanism: the depletion of circMRPS35 reduced the enrichment of histone H3 lysine 23 acetylation (H3K23ac) on forkhead box O3 (FOXO3) promoter in osteosarcoma cells.
Survival: -
Supported No.:
 1
Description:

we concluded that circRNA circMRPS35 repressed progression and induced autophagy of osteosarcoma cells.
Other information
Title:

Circular RNA circMRPS35 regulates progression and autophagy in osteosarcoma cells by recruiting KAT6B to govern FOXO3.

Journal: Anticancer Drugs
Published: 2022/5/4
PubMed ID: 35503036