circRNA basic information
circBase ID: -
Name: hsa_circ_SHKBP1
Synonym: circSHKBP1
Host Gene: hsa-miR-766-5p
 
 
 
Disease basic information
DO ID:
 2876
DO name: laryngeal squamous cell carcinoma
Disease details: laryngeal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human bronchial epithelioid cells (16-HBE), human LSCC cell lines (TU686, AMC-HN-8), human umbilical vascular endothelial cells (HUVECs)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-766-5p
Biological function: Silencing circSHKBP1 expression restrained cell proliferation, invasion, angiogenesis, stem cell-like properties and tumor growth.
Molecular mechanism: Mechanistic analysis clarified that circSHKBP1 sponged hsa-miR-766-5p to regulate HMGA2, the target of hsa-miR-766-5p.
Survival: poor
Supported No.:
 1
Description:

In conclusion, circSHKBP1 accelerated the tumorigenesis of LSCC via modulating HMGA2 by targeting miR-766-5p.
Other information
Title:

Circular RNA CircSHKBP1 accelerates the proliferation, invasion, angiogenesis, and stem cell-like properties via modulation of microR-766-5p/high mobility group AT-hook 2 axis in laryngeal squamous cell carcinoma.

Journal: Bioengineered
Published: 2022/5/4
PubMed ID: 35502885