circRNA basic information
circBase ID: hsa_circ_0005397
Name: -
Synonym: Circ_0005397
Host Gene: hsa-miR-1283
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: HCC cells (Huh-7, SNU-387), liver epithelial cells (THLE-2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1283
Biological function: Circ_0005397 silencing inhibited proliferation, migration, invasion and angiogenesis, while induced apoptosis in HCC cells.
Molecular mechanism: circ_0005397 could sponge hsa-miR-1283, and hsa-miR-1283 could target HEG1.
Survival: -
Supported No.:
 3
Description:

Circ_0005397 regulated HEG1 by targeting miR-1283, thereby promoting HCC development.
Other information
Title:

Circ_0005397 enhances hepatocellular carcinoma progression through miR-1283/HEG1.

Journal: Ann Hepatol
Published: 2022/5/3
PubMed ID: 35500803