circRNA basic information
circBase ID: -
Name: hsa_circ_PTPRM
Synonym: circPTPRM
Host Gene: hsa-miR-139-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal human bronchial epithelial cells (16HE), lung adenocarcinoma cell lines (A549, H1299, PC-9, H1975)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-139-5p
Biological function: knockdown of circPTPRM inhibit proliferation, migration, and invasion of cells can be reversed by mir-139-5p inhibitor.
Molecular mechanism: The target site of hsa-miR-139-5p and focused on SET domain containing 5 (SETD5).
Survival: -
Supported No.:
 1
Description:

We thus conclude that circPTPRM promotes the progression of NSCLC by regulating the miR-139-5p/SETD5 axis.
Other information
Title:

CircRNA PTPRM Promotes Non-Small Cell Lung Cancer Progression by Modulating the miR-139-5p/SETD5 Axis.

Journal: Technol Cancer Res Treat
Published: 2022/5/3
PubMed ID: 35491723