circRNA basic information
circBase ID: hsa_circ_0059961
Name: -
Synonym: circ_0059961
Host Gene: hsa-miR-629-5p
 
 
 
Disease basic information
DO ID:
 4947
DO name: cholangiocarcinoma
Disease details: cholangiocarcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: CCA cell lines (CCLP-1, QBC939), normal biliary cell line (HIBEC)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-629-5p
Biological function: Overexpressed circ_0059961 reduced tumor cell proliferation, migration, and invasion while inducing apoptosis.
Molecular mechanism: Circ_0059961 was proven to be a target of hsa-miR-629-5p, while hsa-miR-629-5p was confirmed to be a target of SFRP2. Circ_0059961 targeted hsa-miR-629-5p to modulate SFRP2 expression.
Survival: -
Supported No.:
 1
Description:

Upregulation of circ_0059961 augmented SFRP2 expression by targeting miR-629-5p, which blocked cholangiocarcinoma tumor cell proliferation, migration, and invasion.
Other information
Title:

Upregulation of circ_0059961 suppresses cholangiocarcinoma development by modulating miR-629-5p/SFRP2 axis.

Journal: Pathol Res Pract
Published: 2022/5/2
PubMed ID: 35490654