circRNA basic information
circBase ID: -
Name: hsa_circ_CRIM1
Synonym: CircCRIM1
Host Gene: hsa-miR-34c-5p
 
 
 
Disease basic information
DO ID:
 9261
DO name: nasopharynx carcinoma
Disease details: nasopharyngeal carcinoma
Species: human
Species details: human
Sample type: cell line
Sample type details: NP69, human nasopharyngeal carcinoma cells (SUNE-1, CNE2, C666-1, CNE-1, HNE1, 5-8F)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-34c-5p
Biological function: Knockdown of circCRIM1 significantly decreased the invasion, viability and migration of NPC cells. The miR-34c-5p inhibitor notably promoted the malignant behaviour of NPC cells, while miR-34c-5p mimics exerted the opposite effect.
Molecular mechanism: circCRIM1 could bind with hsa-miR-34c-5p, and FOSL1 was identified to be downstream of hsa-miR-34c-5p. Furthermore, circCRIM1 downregulation notably inhibited the proliferation and invasion of NPC cells, while this phenomenon was significantly reversed by FOSL1 overexpression.
Survival: -
Supported No.:
 2
Description:

Silencing circCRIM1 inhibited the tumorigenesis of NPC. Thus, circCRIM1 might be a novel target for NPC.
Other information
Title:

CircCRIM1 promotes nasopharyngeal carcinoma progression via the miR-34c-5p/FOSL1 axis.

Journal: Eur J Med Res
Published: 2022/4/29
PubMed ID: 35484574