circRNA basic information
circBase ID: -
Name: hsa_circ_MAN1A2
Synonym: CircMAN1A2
Host Gene: hsa-miR-1236-3p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: AGS, BGC823 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1236-3p
Biological function: The downregulation of circMAN1A2 could inhibit the proliferation, migration and invasion of gastric cancer cells .circMAN1A2 knockdown inhibited xenograft tumour growth in vivo
Molecular mechanism: circMAN1A2 could promote the progression of gastric cancer induced by H. pylori by sponging hsa-miR-1236-3p to regulate MTA2 expression.
Survival: -
Supported No.:
 2
Description:

Helicobacter pylori induced circMAN1A2 expression to promote the carcinogenesis of gastric cancer, and circMAN1A2 might be a new potential diagnostic marker and therapeutic target for gastric cancer.
Other information
Title:

CircMAN1A2 is upregulated by Helicobacter pylori and promotes development of gastric cancer.

Journal: Cell Death Dis
Published: 2022/4/29
PubMed ID: 35484118