circRNA basic information
circBase ID: hsa_circ_0010729
Name: hsa_circ_HSPG2
Synonym: circ_0010729
Host Gene: hsa-miR-665
 
 
 
Disease basic information
DO ID:
 6713
DO name: cerebrovascular disease
Disease details: Ischemic stroke
Species: human
Species details: human
Sample type: cell line
Sample type details: we used oxygen-glucose deprivation/reoxygenation (OGD/R) to stimulate human brain microvascular endothelial cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-665
Biological function: hsa_circ_0010729 silencing promoted OGD/R-induced cell proliferation and inhibited apoptosis. However, the effect of hsa_circ_0010729 down-regulation on OGD/R-induced cell was partially restored after co-transfection with miR-665 inhibitor.
Molecular mechanism: In OGD/R-induced HBMECs, hsa_circ_0010729 silencing decreased ING5 expression by upregulating hsa-miR-665.
Survival: -
Supported No.:
 1
Description:

Hsa_circ_0010729 regulated miR-665/ING5 axis in OGD/R-induced HBMECs. Therefore, hsa_circ_0010729 may be a new therapeutic target for ischemic stroke.
Other information
Title:

Hsa_circ_0010729 is Involved in Oxygen-Glucose Deprivation/Reoxygenation-Induced Human Microvascular Endothelial Cell Deprivation by Targeting miR-665/ING5.

Journal: Biochem Genet
Published: 2022/4/29
PubMed ID: 35482130