circRNA basic information
circBase ID: -
Name: hsa_circ_GOLPH3
Synonym: circGOLPH3
Host Gene: hsa-miR-1299
 
 
 
Disease basic information
DO ID:
 50866
DO name: oral squamous cell carcinoma
Disease details: oral squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: OSCC cell lines
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1299
Biological function: circGOLPH3 promoted the growth of OSCC_n vitro_nd_n vivo. Additionally, circGOLPH3 upregulated OSCC cell migration and invasion.
Molecular mechanism: circGOLPH3 functioned as a microRNA sponge and downregulated hsa-miR-1299 expression. hsa-miR-1299 downregulated the expression of_IF_y targeting its 3-untranslated region. Inhibition of the circGOLPH3/hsa-miR-1299/LIF axis suppressed the growth, migration, and invasion of OSCC cells.
Survival: -
Supported No.:
 2
Description:

These findings indicate that the circGOLPH3/miR-1299/LIF axis promotes OSCC cell growth, migration, and invasion and that this axis is a potential therapeutic target for OSCC.
Other information
Title:

Circular GOLPH3 RNA exerts oncogenic effects in vitro by regulating the miRNA-1299/LIF axis in oral squamous cell carcinoma.

Journal: Bioengineered
Published: 2022/4/29
PubMed ID: 35481460