| Detected method: |
Q
|
| Detected method confidence |
High
|
| Expression pattern: |
|
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-146a |
| Biological function: |
Knockdown of circRNA Fbxl5 ameliorated cardiomyocyte apoptosis, thereby decreasing infarct size and preserving cardiac function. Additionally, in vitro knockdown of circRNA Fbxl5 in NMVMs subjected to AR recapitulated the in vivo findings. |
| Molecular mechanism: |
we identified that circRNA Fbxl5 directly sponged and suppressed the endogenous microRNA-146a (hsa-miR-146a), thereby weakening its inhibitory effect on MED1, which could further promote the apoptosis of cardiomyocytes. |
| Survival: |
- |
Supported
No.: |
1 |
| Description: |
Our findings revealed a novel and critical role for circRNA Fbxl5 in regulating cardiomyocyte apoptosis, and added additional insight into circRNAs mediated during myocardial IRI. The underlying miR-146a-MED1 signaling serves as an important cascade in regulating the apoptosis of cardiomyocytes. |