circRNA basic information
circBase ID: hsa_circ_0072088
Name: -
Synonym: circ_0072088
Host Gene: hsa-miR-1261
 
 
 
Disease basic information
DO ID:
 3910
DO name: lung adenocarcinoma
Disease details: lung adenocarcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: H1299 cells.
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1261
Biological function: it was mainly localized in the cytoplasm and was found to enhance cell proliferation, migration, and invasion of H1299 cells
Molecular mechanism: circ_0072088 directly downregulated hsa-miR-1261 expression, whereas increased PIK3CA gene expression was associated with poor overall survival of LUAD patients.
Survival: poor
Supported No.:
 2
Description:

Circ_0072088-dependent regulation of miR-1261/PIK3CA is important for cell proliferation, migration, and invasion during the tumorigenesis and progression of LUAD, warranting the need to consider the circ_0072088/miR-1261/PIK3CA regulatory pathway as a potential therapeutic target in patients with lung adenocarcinoma.
Other information
Title:

Activation of circ_0072088/miR-1261/PIK3CA pathway accelerates lung adenocarcinoma progression.

Journal: Thorac Cancer
Published: 2022/4/28
PubMed ID: 35474604