circRNA basic information
circBase ID: -
Name: hsa_circ_CCNB1
Synonym: circCCNB1
Host Gene: -
 
 
 
Disease basic information
DO ID:
 9261
DO name: nasopharynx carcinoma
Disease details: nasopharyngeal carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human NPC cell lines (HNE2, CNE2, HONE1, HK1, CNE1,6-10B, HNE1), immortalized normal nasopharyngealepithelial cells (NP69)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: circCCNB1 inhibits NPC cell migration and invasion.
Molecular mechanism: circCCNB1 induces a protein, nuclear factor 90 (NF90), to bind and prolong the half-life of tight junction protein 1 (TJP1) mRNA.
Survival: -
Supported No.:
 1
Description:

This study reveals a novel biological function of circCCNB1 in the migration and invasion of NPC by enhancing the tight junctions of cancer cells by binding to NF90 proteins and TJP1 mRNA, and may provide a potential therapeutic target for NPC.
Other information
Title:

Circular RNA circCCNB1 inhibits the migration and invasion of nasopharyngeal carcinoma through binding and stabilizing TJP1 mRNA.

Journal: Sci China Life Sci
Published: 2022/4/27
PubMed ID: 35471687