circRNA basic information
circBase ID: hsa_circ_0002594
Name: -
Synonym: circ_0002594
Host Gene: hsa-miR-139-5p
 
 
 
Disease basic information
DO ID:
 2841
DO name: asthma
Disease details: asthma
Species: human
Species details: human
Sample type: cell line
Sample type details: human airway smooth muscle cell
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-139-5p
Biological function: circ_0002594 knockdown could suppress PDGF-BB- stimulated HASMC damage.
Molecular mechanism: Mechanism analysis exhibited that circ_0002594 could regulate TRIM8 expression through sponging hsa-miR-139-5p.
Survival: -
Supported No.:
 1
Description:

Our findings revealed that circ_0002594 could act as a regulator in the airway remodelling during asthma development partly by the miR-139-5p/TRIM8 axis, hinting at an underlying therapeutic strategy for asthma.
Other information
Title:

Circular RNA circ_0002594 regulates PDGF-BB-induced proliferation and migration of human airway smooth muscle cells via sponging miR-139-5p/TRIM8 in asthma.

Journal: Autoimmunity
Published: 2022/4/27
PubMed ID: 35470728