circRNA basic information
circBase ID: -
Name: hsa_circ_HIPK3
Synonym: CircHIPK3
Host Gene: hsa-miR-106a-5p
 
 
 
Disease basic information
DO ID:
 1936
DO name: atherosclerosis
Disease details: atherosclerosis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: vascular smooth muscle cell
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-106a-5p
Biological function: Overexpression of circHIPK3 reduced the cell mineralization and calcium content. Overexpression of circHIPK3 inhibited osteogenic differentiation by decreasing ALP activity, RUNX2, and OPG expression, and increasing SM22alpha and SMA level._verexpression of circHIPK3 decreased the chondrogenic differentiation by inhibiting the protein level of SOX9, aggrecan, and collagen II.
Molecular mechanism: CircHIPK3 targeted hsa-miR-106a-5p and hsa-miR-106a-5p targeted MFN2. hsa-miR-106a-5p overexpression or MFN2 depletion repressed the effect of circHIPK3 overexpression on VSMC calcification.
Survival: -
Supported No.:
 2
Description:

CircHIPK3 regulated osteogenic and cartilage differentiation of VSMC via miR-106a-5p/MFN2 axis, indicating a target for treating vascular calcification.
Other information
Title:

CircHIPK3 Regulates Vascular Smooth Muscle Cell Calcification Via the miR-106a-5p/MFN2 Axis.

Journal: J Cardiovasc Transl Res
Published: 2022/4/26
PubMed ID: 35467292