circRNA basic information
circBase ID: -
Name: hsa_circ_KIF4A
Synonym: circKIF4A
Host Gene: hsa-miR-144-3p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: GC cell lines (SGC-7901, BGC-823, MKN-45, HGC-27), a normal gastric epithelial cell line (GES-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-144-3p
Biological function: circKIF4A knockdown suppressed the proliferation, migration, invasion, and EMT of GC cells, while these malignant behaviors were enhanced by circKIF4A overexpression.
Molecular mechanism: we found that circKIF4A was mainly located in the cytoplasm, could directly interact with microRNA- (hsa-miR-) 144-3p, and functions as a miRNA sponge to regulate EZH2 expression in GC cells.
Survival: poor
Supported No.:
 1
Description:

This study indicated that circKIF4A can efficiently sponge miR-144-3p to promote the malignant behaviors of GC cells and may provide a potential biomarker and therapeutic target for GC management.
Other information
Title:

Upregulated Circular RNA KIF4A Promotes Cell Migration and Invasion by Regulating MicroRNA-144-3p/EZH2 Axis in Gastric Cancer.

Journal: J Oncol
Published: 2022/4/26
PubMed ID: 35466313