circRNA basic information
circBase ID: hsa_circ_0088036
Name: -
Synonym: Circ_0088036
Host Gene: hsa-miR-1263
 
 
 
Disease basic information
DO ID:
 7148
DO name: rheumatoid arthritis
Disease details: rheumatoid arthritis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HFLS
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1263
Biological function: Functionally, overexpression of miR-1263 suppressed the development of HFLS-RA by blocking the NF-¦ĘB pathway, and this phenomenon was reversed by the upregulation of REL.
Molecular mechanism: The hsa-miR-1263 was identified as a target of circ_0088036. hsa-miR-1263 was found to be down-regulated in sera and in HFLS cells of RA patients. The regulatory effects of circ_0088036 on HFLS-RA cells were attributed to inhibit the hsa-miR-1263 level. REL is a susceptibility locus for certain autoimmune diseases. hsa-miR-1263 directly targeted REL, which was discovered to be elevated in sera and HFLS cells of RA patients, and circ_0088036 interacted with hsa-miR-1263 to affect REL expression.
Survival: -
Supported No.:
 3
Description:

These findings suggested that circ_0088036/miR-1263/REL/NF-¦ĘB pathway was involved in the functional development of HFLS-RA cells, indicating a novel molecular network in RA progression in vitro.
Other information
Title:

Circ_0088036 mediated progression and inflammation in fibroblast-like synoviocytes of rheumatoid arthritis by miR-1263/REL-activated NF-kappaB pathway.

Journal: Transpl Immunol
Published: 2022/4/24
PubMed ID: 35460876