circRNA basic information
circBase ID: -
Name: hsa_circ_MTHFD1L
Synonym: circ-MTHFD1L
Host Gene: hsa-miR-615-3p
 
 
 
Disease basic information
DO ID:
 3498
DO name: pancreatic ductal adenocarcinoma
Disease details: pancreatic ductal adenocarcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human PDAC cells (PATU8988T, AsPC-1, BxPC-3, PANC-1, SW1990), human pancreatic ductal epithelial (HPDE) cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-615-3p
Biological function: circ-MTHFD1L promot DNA damage repair and exerting its effect on enhancing gemcitabine chemotherapy resistance.
Molecular mechanism: circ-MTHFD1L, as an endogenous hsa-miR-615-3p sponge, upregulates the expression of RPN6
Survival: poor
Supported No.:
 1
Description:

Circ-MTHFD1L maintains PDAC gemcitabine resistance through the miR-615-3p/RPN6 signal axis. Circ-MTHFD1L may be a molecular marker for the effective treatment of PDAC.
Other information
Title:

Circular RNA circ-MTHFD1L induces HR repair to promote gemcitabine resistance via the miR-615-3p/RPN6 axis in pancreatic ductal adenocarcinoma.

Journal: J Exp Clin Cancer Res
Published: 2022/4/24
PubMed ID: 35459186