circRNA basic information
circBase ID: hsa_circ_0087207
Name: hsa_circ_ALDH1A1
Synonym: -
Host Gene: hsa-miR-665
 
 
 
Disease basic information
DO ID:
 705
DO name: Leber hereditary optic neuropathy
Disease details: Leber hereditary optic neuropathy
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: retinal ganglion cells
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-665
Biological function: Overexpression of hsa_circ_0087207 increased the apoptosis in carrier iPSC-derived RGCs, while knockdown of hsa_circ_0087207 attenuated the apoptosis in LHON-patient iPSC-derived RGCs.
Molecular mechanism: hsa_circ_0087207 acts as the sponge of hsa-miR-665 to induce the expression of a variety of apoptosis-related genes in LHON patient iPSC-derived RGCs.
Survival: -
Supported No.:
 1
Description:

Our data indicated that hsa_circ_0087207 upregulation distinguishes the disease phenotype manifestations between iPSC-derived RGCs generated from the LHON patient and carrier. Targeting the hsa_circ_0087207/miR-665 axis might hold therapeutic promises for the treatment of LHON.
Other information
Title:

Retinal Circular RNA hsa_circ_0087207 Expression Promotes Apoptotic Cell Death in Induced Pluripotent Stem Cell-Derived Leber Hereditary Optic Neuropathy-like Models.

Journal: Biomedicines
Published: 2022/4/24
PubMed ID: 35453537