circRNA basic information
circBase ID: -
Name: hsa_circ_ACTR2
Synonym: CircACTR2
Host Gene: hsa-miR-561
 
 
 
Disease basic information
DO ID:
 0050855
DO name: renal fibrosis
Disease details: renal fibrosis
Species: human
Species details: human
Sample type: cell line
Sample type details: macrophages, tubular epithelial cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-561
Biological function: CircACTR2 sufficiently and essentially promoted the activation of NLRP3 inflammasome, pyroptosis, and inflammation in macrophages, and through paracrine effect, stimulated EMT and fibrosis of TECs.
Molecular mechanism: circACTR2 sponged hsa-miR-561 and up-regulated NLRP3 expression level to induce the secretion of IL-1beta. In TECs, IL-1beta induced renal fibrosis via up-regulating fascin-1. Knocking down circACTR2 or elevating hsa-miR-561 potently alleviated renal fibrosis in vivo
Survival: -
Supported No.:
 1
Description:

In summary, circACTR2, by sponging miR-561, activated NLRP3 inflammasome, promoted macrophage inflammation, and stimulated macrophage-induced EMT and fibrosis of TECs. Knocking down circACTR2 and overexpressing miR-561 may, thus, benefit the treatment of renal fibrosis.
Other information
Title:

CircACTR2 in macrophages promotes renal fibrosis by activating macrophage inflammation and epithelial-mesenchymal transition of renal tubular epithelial cells.

Journal: Cell Mol Life Sci
Published: 2022/4/23
PubMed ID: 35449370