circRNA basic information
circBase ID: -
Name: hsa_circ_TLK1
Synonym: circTLK1
Host Gene: hsa-miR-26a-5p
 
 
 
Disease basic information
DO ID:
 14330
DO name: Parkinson disease
Disease details: Parkinson disease
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: human neuroblastoma cell line (SH-SY5Y), murine dopaminergic cell line (MN9D)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-26a-5p
Biological function: Knockdown of circTLK1 significantly improved cell viability, suppressed apoptosis and cytotoxicity, whereas inhibition of miR-16a-5p and overexpression of DAPK1 abolished these effects.
Molecular mechanism: hsa-miR-26a-5p acts as a sponge of DAPK1 to mediate circTLK1 functions. Luciferase reporter gene assay confirmed the interaction between circTLK1 and hsa-miR-26a-5p as well as hsa-miR-26a-5p and DAPK1.
Survival: -
Supported No.:
 1
Description:

Depletion of circTLK1 mitigates dopaminergic neuron injury in vitro and in vivo, via releasing miR-26a-5p to target DAPK1 expression. Targeting circTLK1 may contribute to improving PD therapy.
Other information
Title:

Circular RNA circTLK1 regulates dopaminergic neuron injury during Parkinson disease by targeting miR-26a-5p/DAPK1.

Journal: Neurosci Lett
Published: 2022/4/22
PubMed ID: 35447224