circRNA basic information
circBase ID: hsa_circ_0000285
Name: hsa_circ_HIPK3
Synonym: circ_0000285
Host Gene: hsa-miR-127-5p
 
 
 
Disease basic information
DO ID:
 1781
DO name: thyroid gland cancer
Disease details: thyroid cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: THCA cells.
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-127-5p
Biological function: The downregulation of hsa_circ_0000285 weakened the proliferative and migratory capacity of THCA cells and promoted cell apoptosis.
Molecular mechanism: hsa_circ_0000285 might target hsa-miR-127-5p/CDH2 axis in THCA.
Survival: -
Supported No.:
 3
Description:

hsa_circ_0000285 induced the development of THCA via functioning as a competing endogenous RNA (ceRNA) of miR-127-5p to enhance CDH2 expression, which provided a new perspective for THCA therapy.
Other information
Title:

hsa_circ_0000285 facilitates thyroid cancer progression by regulating miR-127-5p/CDH2.

Journal: J Clin Lab Anal
Published: 2022/4/22
PubMed ID: 35447001