circRNA basic information
circBase ID: -
Name: hsa_circ_HIPK3
Synonym: circHIPK3
Host Gene: hsa-miR-124
 
 
 
Disease basic information
DO ID:
 3748
DO name: esophagus squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: KYSE-150, KYSE-410 cells .ECA-109, KYSE180 cells, a normal human esophageal epithelial cell line (HEEC)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-124
Biological function: silencing of circHIPK3 expression retarded esophageal cancer cell proliferation, migration and epithelial-mesenchymal transition (EMT)_n vitro, as well as the growth_n vivo.
Molecular mechanism: circHIPK3 behaved like a sponge, absorbing microRNA-124 (hsa-miR-124) and promoting serine/threonine kinase 3 (AKT3) expression.
Survival: poor
Supported No.:
 1
Description:

Our findings indicate that circHIPK3 acts as an oncogene in ESCC and that the circHIPK3-AKT3_xis may be a therapeutic target for patients with ESCC.
Other information
Title:

circHIPK3 regulates cell proliferation and migration by sponging microRNA-124 and regulating serine/threonine kinase 3 expression in esophageal squamous cell carcinoma.

Journal: Bioengineered
Published: 2022/4/22
PubMed ID: 35443871