circRNA basic information
circBase ID: -
Name: hsa_circ_MYC
Synonym: CircMYC
Host Gene: hsa-miR-145
 
 
 
Disease basic information
DO ID:
 1324
DO name: lung cancer
Disease details: lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human SCLC cell lines, human bronchial epithelial cell line (16-HBE)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-145
Biological function: Knockdown of circMYC could inhibit cell proliferation, migration, invasion, and induce apoptosis.
Molecular mechanism: CircMYC targeted hsa-miR-145 and hsa-miR-145 targeted MMP2 (Matrix Metallopeptidase 2) mRNA.
Survival: -
Supported No.:
 1
Description:

These findings suggest that targeting circMYC/miR-145/MMP-2 could serve as a potential therapeutic strategy for SCLC treatment.
Other information
Title:

CircMYC promotes proliferation, migration, invasion and inhibits apoptosis of small cell lung cancer by targeting miR-145/ Matrix Metallopeptidase 2 axis.

Journal: Bioengineered
Published: 2022/4/21
PubMed ID: 35441564