circRNA basic information
circBase ID: -
Name: hsa_circ_HECTD1
Synonym: circHECTD1
Host Gene: hsa-miR-136, hsa-miR-320a
 
 
 
Disease basic information
DO ID:
 850
DO name: lung disease
Disease details: acute lung injury
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: HBE, MLE-12
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-136, hsa-miR-320a
Biological function: The knockdown of circHECTD1 increased the apoptotic rates and the expressions of miR-136 and miR-320a, while its overexpression caused opposite effects in LPS-induced HBE and MLE-12 cells.
Molecular mechanism: circHECTD1 bound to hsa-miR-320a and hsa-miR-136. hsa-miR-320a targeted PIK3CA and mediated the effect of circHECTD1 on PIK3CA expression.
Survival: -
Supported No.:
 1
Description:

Our findings suggested that circHECTD1 inhibits the apoptosis of AECs through miR-320a/PIK3CA and miR-136/Sirt1 pathways in LPS-induced ALI.
Other information
Title:

circHECTD1 attenuates apoptosis of alveolar epithelial cells in acute lung injury.

Journal: Lab Invest
Published: 2022/4/21
PubMed ID: 35440759