circRNA basic information
circBase ID: hsa_circ_0071336
Name: hsa_circ_FNIP2
Synonym: -
Host Gene: hsa-miR-93-5p
 
 
 
Disease basic information
DO ID:
 9352
DO name: type 2 diabetes mellitus
Disease details: type 2 diabetes
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HEK-293T, 3T3-L1
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-93-5p
Biological function: Low expression of circ_0071336 was an independent predictor of T2D, IFG and insulin resistance.
Molecular mechanism: a luciferase reporter assay and western-blot analysis indicated that hsa-miR-93-5p was a direct target of hsa_circ_0071336, and hsa-miR-93-5p may negatively regulate the expression of GLUT4.
Survival: -
Supported No.:
 1
Description:

In conclusion, hsa_circRNA_0071336 can be considered as a potential novel and stable biomarker for T2D and its early detection. hsa_circ_0071336 regulates the GLUT4 expression by sponging miR-93-5p and maybe involved in the pathogenesis of T2D. These findings may unveil new targets for the prevention, diagnosis and treatment of T2D.
Other information
Title:

CircRNA hsa_circ_0071336 is associated with type 2 diabetes through targeting the miR-93-5p/GLUT4 axis.

Journal: FASEB J
Published: 2022/4/20
PubMed ID: 35439323