circRNA basic information
circBase ID: -
Name: hsa_circ_LPAR3
Synonym: circLPAR3
Host Gene: hsa-miR-144-3p
 
 
 
Disease basic information
DO ID:
 50866
DO name: oral squamous cell carcinoma
Disease details: oral squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: SCC9, SCC4, SCC25. UM1), HSC3, CAL27
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-144-3p
Biological function: circLPAR3 inhibition decreased OSCC growth in xenograft mouse models. Moreover, circLPAR3 silencing repressed cell proliferation, migration, invasion, angiopoiesis, glycolysis, and induced cell apoptosis in OSCC cells in vitro.
Molecular mechanism: circLPAR3 sponged hsa-miR-144-3p to prohibit the inhibiting effect of hsa-miR-144-3p on LPCAT1, thus promoting OSCC progression.
Survival: poor
Supported No.:
 3
Description:

CircLPAR3 exerted a tumor-promoting effect on OSCC growth through elevating LPCAT1 expression via functioning as a miR-144-3p sponge. This study supports the possible role of circLPAR3 in the diagnosis, prognosis, and treatment of OSCC.
Other information
Title:

Downregulation of circLPAR3 inhibits tumor progression and glycolysis by liberating miR-144-3p and upregulating LPCAT1 in oral squamous cell carcinoma.

Journal: Laryngoscope Investig Otolaryngol
Published: 2022/4/19
PubMed ID: 35434335